Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]‐FP‐CIT SPECT imaging: The [123I]‐FP‐CIT study group
Identifieur interne : 004B59 ( Main/Exploration ); précédent : 004B58; suivant : 004B60Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]‐FP‐CIT SPECT imaging: The [123I]‐FP‐CIT study group
Auteurs : Hani T. S. Benamer [Royaume-Uni] ; Jim Patterson [Royaume-Uni] ; Donald G. Grosset [Royaume-Uni] ; J. Booij [Royaume-Uni] ; K. De Bruin [Royaume-Uni] ; E. Van Royen [Royaume-Uni] ; J. D. Speelman [Pays-Bas] ; M. H. I. M. Horstink [Pays-Bas] ; H. J. W. A. Sips [Pays-Bas] ; R. A. Dierckx [Belgique] ; J. Versijpt [Belgique] ; D. Decoo [Belgique] ; C. Van Der Linden [Belgique] ; D. M. Hadley ; M. Doder [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; D. C. Costa [Royaume-Uni] ; S. Gacinovic [Royaume-Uni] ; W. H. Oertel [Allemagne] ; O. Pogarell [Allemagne] ; H. Hoeffken [Allemagne] ; K. Joseph [Allemagne] ; K. Tatsch [Belgique] ; J. Schwarz [Allemagne] ; V. Ries [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
OBJECTIVE: To evaluate whether visual assessment of [123I]‐FP‐CIT (DaTSCAN , Nycomed Amersham, plc) single photon emission computerized tomography (SPECT) images can differentiate between parkinsonism and essential tremor (ET). METHODS: [123I]‐FP‐CIT SPECT imaging was conducted in a six‐center study of 158 patients with a clinical diagnosis of parkinsonism compared with 27 ET cases and 35 healthy volunteers. Striatal uptake of the radioligand was graded normal or abnormal, and abnormal images were further graded to three levels of severity. An institutional read whereby each center visually assessed the images blinded to the clinical data and a consensus blinded read by a panel of five was undertaken. RESULTS: The institutional reading scored 154 of 158 cases of parkinsonism abnormal, all 27 cases of ET as normal, and 34 of 35 healthy volunteers as normal compared with the consensus blinded read scoring 150 cases of parkinsonism as abnormal, 25 ET cases as normal, and 33 healthy volunteers as normal. Sensitivity for the clinical diagnosis of parkinsonism was 97% and specificity for ET was 100% for the institutional read, whereas sensitivity was 95% and specificity 93% for the consensus blinded read. Semiquantitative analysis of specific: nonspecific caudate and putamen uptake were consistent with the results of visual inspection. CONCLUSION: Visual assessment of [123I]‐FP‐CIT SPECT images is an easily applied diagnostic test which is helpful in the differential diagnosis of tremor disorders and in confirming a clinical diagnosis of a hypokinetic‐rigid syndrome.
Url:
DOI: 10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V
Affiliations:
- Allemagne, Belgique, Pays-Bas, Royaume-Uni
- Angleterre, Bade-Wurtemberg, District de Giessen, District de Tübingen, Grand Londres, Gueldre, Hesse (Land), Hollande-Septentrionale
- Amsterdam, Londres, Marbourg, Nimègue, Ulm
- National Hospital for Neurology and Neurosurgery, Université d'Ulm
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De Bruin</name></author><author><name sortKey="Van Royen, E" sort="Van Royen, E" uniqKey="Van Royen E" first="E." last="Van Royen">E. Van Royen</name></author><author><name sortKey="Speelman, J D" sort="Speelman, J D" uniqKey="Speelman J" first="J. D." last="Speelman">J. D. Speelman</name></author><author><name sortKey="Horstink, M H I M" sort="Horstink, M H I M" uniqKey="Horstink M" first="M. H. I. M." last="Horstink">M. H. I. M. Horstink</name></author><author><name sortKey="Sips, H J W A" sort="Sips, H J W A" uniqKey="Sips H" first="H. J. W. A." last="Sips">H. J. W. A. Sips</name></author><author><name sortKey="Dierckx, R A" sort="Dierckx, R A" uniqKey="Dierckx R" first="R. A." last="Dierckx">R. A. Dierckx</name></author><author><name sortKey="Versijpt, J" sort="Versijpt, J" uniqKey="Versijpt J" first="J." last="Versijpt">J. Versijpt</name></author><author><name sortKey="Decoo, D" sort="Decoo, D" uniqKey="Decoo D" first="D." last="Decoo">D. 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S." last="Benamer">Hani T. S. Benamer</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurological Sciences, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Patterson, Jim" sort="Patterson, Jim" uniqKey="Patterson J" first="Jim" last="Patterson">Jim Patterson</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurological Sciences, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurological Sciences, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Booij, J" sort="Booij, J" uniqKey="Booij J" first="J." last="Booij">J. Booij</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurological Sciences, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="De Bruin, K" sort="De Bruin, K" uniqKey="De Bruin K" first="K." last="De Bruin">K. De Bruin</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurological Sciences, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Van Royen, E" sort="Van Royen, E" uniqKey="Van Royen E" first="E." last="Van Royen">E. Van Royen</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurological Sciences, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Speelman, J D" sort="Speelman, J D" uniqKey="Speelman J" first="J. D." last="Speelman">J. D. Speelman</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Departments of Nuclear Medicine and Neurology, Academisch Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Horstink, M H I M" sort="Horstink, M H I M" uniqKey="Horstink M" first="M. H. I. M." last="Horstink">M. H. I. M. Horstink</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Sips, H J W A" sort="Sips, H J W A" uniqKey="Sips H" first="H. J. W. A." last="Sips">H. J. W. A. Sips</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Hospital Nijmegen, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Dierckx, R A" sort="Dierckx, R A" uniqKey="Dierckx R" first="R. A." last="Dierckx">R. A. Dierckx</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Afdeling Nucleaire Geneeskunde, Universitat Ziekenhuis Ghent, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Versijpt, J" sort="Versijpt, J" uniqKey="Versijpt J" first="J." last="Versijpt">J. Versijpt</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Afdeling Nucleaire Geneeskunde, Universitat Ziekenhuis Ghent, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Decoo, D" sort="Decoo, D" uniqKey="Decoo D" first="D." last="Decoo">D. Decoo</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Elisabeth Ziekenhuis Sijsele, Sijsele</wicri:regionArea><wicri:noRegion>Sijsele</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Linden, C" sort="Van Der Linden, C" uniqKey="Van Der Linden C" first="C." last="Van Der Linden">C. Van Der Linden</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Elisabeth Ziekenhuis Sijsele, Sijsele</wicri:regionArea><wicri:noRegion>Sijsele</wicri:noRegion></affiliation></author><author><name sortKey="Hadley, D M" sort="Hadley, D M" uniqKey="Hadley D" first="D. M." last="Hadley">D. M. Hadley</name><affiliation><wicri:noCountry code="no comma">Department of Neuro‐Radiology</wicri:noCountry></affiliation></author><author><name sortKey="Doder, M" sort="Doder, M" uniqKey="Doder M" first="M." last="Doder">M. Doder</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A. J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="Costa, D C" sort="Costa, D C" uniqKey="Costa D" first="D. C." last="Costa">D. C. Costa</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Nuclear Medicine, UCL, Middlesex Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gacinovic, S" sort="Gacinovic, S" uniqKey="Gacinovic S" first="S." last="Gacinovic">S. Gacinovic</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Nuclear Medicine, UCL, Middlesex Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Philipps Universitat, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Philipps Universitat, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hoeffken, H" sort="Hoeffken, H" uniqKey="Hoeffken H" first="H." last="Hoeffken">H. Hoeffken</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum der Philipps Universitat, Med Zentrum fur Radiologie, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Joseph, K" sort="Joseph, K" uniqKey="Joseph K" first="K." last="Joseph">K. Joseph</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinikum der Philipps Universitat, Med Zentrum fur Radiologie, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Tatsch, K" sort="Tatsch, K" uniqKey="Tatsch K" first="K." last="Tatsch">K. Tatsch</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Afdeling Nucleaire Geneeskunde, Universitat Ziekenhuis Ghent, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Schwarz, J" sort="Schwarz, J" uniqKey="Schwarz J" first="J." last="Schwarz">J. Schwarz</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Ries, V" sort="Ries, V" uniqKey="Ries V" first="V." last="Ries">V. Ries</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-05">2000-05</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="503">503</biblScope><biblScope unit="page" to="510">510</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1D31C6201015797704658D8A71DE1CE42B311E85</idno><idno type="DOI">10.1002/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V</idno><idno type="ArticleID">MDS1013</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (vertebrata)</term><term>Differential diagnostic</term><term>Emission tomography</term><term>Essential</term><term>Essential tremor</term><term>Human</term><term>Multicenter study</term><term>Parkinsonism</term><term>Photon</term><term>Tremor</term><term>[123I]‐FP‐CIT—SPECT</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Diagnostic différentiel</term><term>Encéphale</term><term>Essentiel</term><term>Etude multicentrique</term><term>Homme</term><term>Parkinsonisme</term><term>Photon</term><term>Tomoscintigraphie</term><term>Tremblement</term><term>[123I]-FP-CIT</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">OBJECTIVE: To evaluate whether visual assessment of [123I]‐FP‐CIT (DaTSCAN , Nycomed Amersham, plc) single photon emission computerized tomography (SPECT) images can differentiate between parkinsonism and essential tremor (ET). METHODS: [123I]‐FP‐CIT SPECT imaging was conducted in a six‐center study of 158 patients with a clinical diagnosis of parkinsonism compared with 27 ET cases and 35 healthy volunteers. Striatal uptake of the radioligand was graded normal or abnormal, and abnormal images were further graded to three levels of severity. An institutional read whereby each center visually assessed the images blinded to the clinical data and a consensus blinded read by a panel of five was undertaken. RESULTS: The institutional reading scored 154 of 158 cases of parkinsonism abnormal, all 27 cases of ET as normal, and 34 of 35 healthy volunteers as normal compared with the consensus blinded read scoring 150 cases of parkinsonism as abnormal, 25 ET cases as normal, and 33 healthy volunteers as normal. Sensitivity for the clinical diagnosis of parkinsonism was 97% and specificity for ET was 100% for the institutional read, whereas sensitivity was 95% and specificity 93% for the consensus blinded read. Semiquantitative analysis of specific: nonspecific caudate and putamen uptake were consistent with the results of visual inspection. CONCLUSION: Visual assessment of [123I]‐FP‐CIT SPECT images is an easily applied diagnostic test which is helpful in the differential diagnosis of tremor disorders and in confirming a clinical diagnosis of a hypokinetic‐rigid syndrome.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>District de Giessen</li><li>District de Tübingen</li><li>Grand Londres</li><li>Gueldre</li><li>Hesse (Land)</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Londres</li><li>Marbourg</li><li>Nimègue</li><li>Ulm</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li><li>Université d'Ulm</li></orgName></list><tree><noCountry><name sortKey="Hadley, D M" sort="Hadley, D M" uniqKey="Hadley D" first="D. M." last="Hadley">D. M. Hadley</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Benamer, Hani T S" sort="Benamer, Hani T S" uniqKey="Benamer H" first="Hani T. S." last="Benamer">Hani T. S. Benamer</name></noRegion><name sortKey="Booij, J" sort="Booij, J" uniqKey="Booij J" first="J." last="Booij">J. Booij</name><name sortKey="Costa, D C" sort="Costa, D C" uniqKey="Costa D" first="D. C." last="Costa">D. C. Costa</name><name sortKey="De Bruin, K" sort="De Bruin, K" uniqKey="De Bruin K" first="K." last="De Bruin">K. De Bruin</name><name sortKey="Doder, M" sort="Doder, M" uniqKey="Doder M" first="M." last="Doder">M. Doder</name><name sortKey="Gacinovic, S" sort="Gacinovic, S" uniqKey="Gacinovic S" first="S." last="Gacinovic">S. Gacinovic</name><name sortKey="Grosset, Donald G" sort="Grosset, Donald G" uniqKey="Grosset D" first="Donald G." last="Grosset">Donald G. Grosset</name><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A. J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Patterson, Jim" sort="Patterson, Jim" uniqKey="Patterson J" first="Jim" last="Patterson">Jim Patterson</name><name sortKey="Van Royen, E" sort="Van Royen, E" uniqKey="Van Royen E" first="E." last="Van Royen">E. Van Royen</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Speelman, J D" sort="Speelman, J D" uniqKey="Speelman J" first="J. D." last="Speelman">J. D. Speelman</name></region><name sortKey="Horstink, M H I M" sort="Horstink, M H I M" uniqKey="Horstink M" first="M. H. I. M." last="Horstink">M. H. I. M. Horstink</name><name sortKey="Sips, H J W A" sort="Sips, H J W A" uniqKey="Sips H" first="H. J. W. A." last="Sips">H. J. W. A. Sips</name></country><country name="Belgique"><noRegion><name sortKey="Dierckx, R A" sort="Dierckx, R A" uniqKey="Dierckx R" first="R. A." last="Dierckx">R. A. Dierckx</name></noRegion><name sortKey="Decoo, D" sort="Decoo, D" uniqKey="Decoo D" first="D." last="Decoo">D. Decoo</name><name sortKey="Tatsch, K" sort="Tatsch, K" uniqKey="Tatsch K" first="K." last="Tatsch">K. Tatsch</name><name sortKey="Van Der Linden, C" sort="Van Der Linden, C" uniqKey="Van Der Linden C" first="C." last="Van Der Linden">C. Van Der Linden</name><name sortKey="Versijpt, J" sort="Versijpt, J" uniqKey="Versijpt J" first="J." last="Versijpt">J. Versijpt</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name></region><name sortKey="Hoeffken, H" sort="Hoeffken, H" uniqKey="Hoeffken H" first="H." last="Hoeffken">H. Hoeffken</name><name sortKey="Joseph, K" sort="Joseph, K" uniqKey="Joseph K" first="K." last="Joseph">K. Joseph</name><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name><name sortKey="Ries, V" sort="Ries, V" uniqKey="Ries V" first="V." last="Ries">V. Ries</name><name sortKey="Schwarz, J" sort="Schwarz, J" uniqKey="Schwarz J" first="J." last="Schwarz">J. Schwarz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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